Tretinoin (Retin-A, Avita, Renova) is a derivative of Vitamin A and is the treatment of choice for comedonal acne, or whiteheads and blackheads. It works by increasing skin cell turnover promoting the extrusion of the plugged material in the follicle. It also prevents the formation of new comedones. Tretinoin is also the only topical medication that has been proven to improve wrinkles.

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